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‘Zinc fingers’: a novel protein motif for nucleic acid recognition

Authors
Journal
Trends in Biochemical Sciences
0968-0004
Publisher
Elsevier
Publication Date
Volume
12
Identifiers
DOI: 10.1016/0968-0004(87)90231-3
Disciplines
  • Biology

Abstract

Abstract In the last few years a novel protein motif used for binding to DNA (and RNA) has emerged, conveniently called the ‘Zn finger’. It was originally discovered repeated in tandem in the Xenopus transcription factor IIIA, but it is now clear that it is ubiquitous. Putative Zn fingers are present in different numbers within the structure of many regulatory proteins and serve as modules for the building up of a specific nucleic acid binding domain.

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