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3-Quinuclidinol as a nucleophilic catalyst for the cyanation of 2-chloropyrimidines

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Identifiers
DOI: 10.1016/j.tetlet.2014.07.033
Keywords
  • 3-Quinuclidinol
  • Cyanation
  • Cyanopyrimidine
  • Nucleophilic Catalyst
  • Dabco

Abstract

Abstract 3-Quinuclidinol serves as an effective nucleophilic catalyst for the preparation of 2-cyanopyrimidines by cyanation of 2-chloropyrimidines with potassium cyanide in good yields.

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