Affordable Access

Publisher Website

Silver salt-promoted direct cross-coupling reactions of alkynylsilanes with aryl iodides: synthesis of aryl-substituted alkynylamides

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
41
Issue
14
Identifiers
DOI: 10.1016/s0040-4039(00)00167-2
Keywords
  • Alkynes
  • Coupling Reactions
  • Silicon And Compounds
  • Palladium Catalyst

Abstract

Abstract A direct cross-coupling reaction of 5-trimethylsilyl-4-pentynamides (alkynylsilanes) 1 with aryl iodides, promoted by silver carbonate in the presence of palladium catalyst, afforded aryl-substituted alkynylamides 2, which readily underwent cyclization to form benzylidenelactams 3. This coupling reaction proved to be a useful for synthesis of aryl-substituted alkynes.

There are no comments yet on this publication. Be the first to share your thoughts.