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Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
19
Issue
20
Identifiers
DOI: 10.1016/j.bmcl.2009.08.070
Keywords
  • Dna
  • Threading Intercalators
  • Acridines
  • Benzyne Click Chemistry
Disciplines
  • Chemistry

Abstract

Abstract A small set of 9-aminoacridine-3- and 4-carboxamides were synthesized efficiently using the benzyne/azide click chemistry. The products bind to duplex DNA but have different antitumour activity in the HL60 cell line.

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