Affordable Access

Publisher Website

Viremia and neutralizing antibody response in infants with exanthem subitum

Authors
Journal
The Journal of Pediatrics
0022-3476
Publisher
Elsevier
Publication Date
Volume
114
Issue
4
Identifiers
DOI: 10.1016/s0022-3476(89)80689-4
Disciplines
  • Medicine

Abstract

Mononuclear cell-associated viremia caused by human herpesvirus type 6 was detected in 39 (66%) of 59 blood samples from 38 children with exanthem subitum between day 0 and day 7 of the disease. The rate of virus isolation from mononuclear cells was 100% (26/26) on days 0 to 2 (just before appearance of skin rash), 82% (9/11) on day 3,20% (2/10) on day 4,7% (2/12) on days 5 to 7, and 0% (0/37) on day 8 and thereafter. The cell-free virus was detected in blood in 10 (21%) of 47 blood samples during the same period. The antibody activity to the virus, evaluated by a newly developed neutralization assay, was first detected on day 3 of the disease with a positive rate of 18% (2/11). It became 60% (6/10) on day 4, 75% (9/12) on days 5 to 7, and 100% on day 8 and thereafter. Thus the disappearance of the virus from blood was associated with the induction of specific immunity to the virus.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Viremia and neutralizing antibody response in infa...

on The Journal of Pediatrics April 1989

[Anti-EB virus antibody response in exanthema subi...

on Saishin igaku. Modern medicine April 1971

Severity of human herpesvirus-6 viremia and clinic...

on The Journal of Pediatrics June 1991

Severity of human herpesvirus-6 viremia and clinic...

on The Journal of Pediatrics Jan 01, 1991
More articles like this..