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Possible effects of the synthetic amino acid, L-ethionine, on memory in rats

Authors
Journal
Physiology & Behavior
0031-9384
Publisher
Elsevier
Publication Date
Volume
22
Issue
5
Identifiers
DOI: 10.1016/0031-9384(79)90348-2
Keywords
  • Memory
  • Amnesia
  • Drugs
  • Learning

Abstract

Abstract Two experiments to explore the behavioral effects of injections of the synthetic amino acid L-ethionine indicated that this drug interferes with the performance of a learned passive avoidance response. Additionally, this deficit was found to occur in the absence of detectable changes in gross motor activity. Because this effect was found when the drug was injected near the time of training, but not when it was injected before testing, and because the effect was found to persist after the drug is believed to have been eliminated from the blood stream, the data were interpreted as reflecting a possible effect upon some aspect of memory functioning.

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