Affordable Access

Publisher Website

Is there a climatic influence on the blood level of anticonvolsive drugs?

Authors
Journal
Medical Hypotheses
0306-9877
Publisher
Elsevier
Publication Date
Volume
8
Issue
4
Identifiers
DOI: 10.1016/0306-9877(82)90037-8
Disciplines
  • Biology

Abstract

Abstract The diphenylhydantoin concentration in ten treated epileptics was determined during a period of two years in Tel-Aviv, Israel where subtropical climate prevails. The data collected showed a significant decrease at the end of Summer and a significant increase at the end of Winter. Since diphenylhydantoin is excreted in the sweat and sweating is excessive during the Summer months in the area where the study was under-taken, it is suggested that the increase of perspiration is responsible for the drop of diphenylhdantoin serum concentration. No other seasonal biological rhythms are known to us which could be incriminating.

There are no comments yet on this publication. Be the first to share your thoughts.