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The theory of clonal mixing during growth

Authors
Journal
Journal of Theoretical Biology
0022-5193
Publisher
Elsevier
Publication Date
Volume
39
Issue
1
Identifiers
DOI: 10.1016/0022-5193(73)90204-x

Abstract

Abstract The component clones of an embryo may mingle as they grow. The pattern which results from clonal mixing can be seen in adult genetic mosaics. This paper relates the final type and degree of mixing to the random diffusive mobility of individual cells during growth. It is shown that mixing is slight if d ⪡ a, and extensive if d ⪢ a, where a is the average distance between neighbouring cells, and d is the average distance through which a cell diffuses in the course of one cell cycle.

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