Affordable Access

Publisher Website

Regulation by SREBP-2 defines a potential link between isoprenoid and adenosylcobalamin metabolism

Elsevier Inc.
Publication Date
DOI: 10.1016/j.bbrc.2007.01.155
  • Mevalonate Kinase
  • Cob(I)Alamin Adenotransferase
  • Cholesterol
  • Srebp
  • Atorvastatin


Abstract Mevalonate kinase (MVK) catalyses an early step in cholesterol biosynthesis converting mevalonate to phosphomevalonate. Cob(I)alamin adenosyltransferase (MMAB) converts cob(I)alamin to adenosylcobalamin, functionally required for mitochondrial methylmalonyl-CoA mutase activity and succinyl-CoA formation. These two synthenic genes are found in a head-to-head formation on chromosome 12 in man and chromosome 5 in mouse. The 330 bp intergenic region showed several conserved NF-Y sites indicative of potential bidirectional regulatory SREBP synergism. Both MVK and MMAB appear to be regulated in a similar manner, to a large extent by SREBP-2, since their tissue expression pattern was similar and both genes were suppressed by an excess of cholesterol as well as SREBP-2 knockdown. Statin treatment in mice upregulated both Mvk and Mmab mRNA levels indicating that this treatment may be useful in inborn errors of cblB complementation associated with methylmalonic aciduria as well as hyper IgD and periodic fever syndrome (HIDS).

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

Regulation by SREBP-2 defines a potential link bet...

on Biochemical and Biophysical Re... Apr 06, 2007

[SREBP2 and cholesterol metabolism].

on Nihon rinsho. Japanese journal... February 2001

Regulation of the bovine SCD5 promoter by EGR2 and...

on Biochemical and Biophysical Re... May 04, 2012
More articles like this..