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Using force to visualize conformational activation of integrins

Authors
Journal
The Journal of Cell Biology
0021-9525
Publisher
The Rockefeller University Press
Publication Date
Volume
199
Issue
3
Identifiers
DOI: 10.1083/jcb.201209073
Keywords
  • Reviews
  • Comment
Disciplines
  • Physics

Abstract

The development of biophysical approaches to analyze integrin–ligand binding allows us to visualize in real time the conformational changes that shift the bond affinity between low- and high-affinity states. In this issue, Chen et al. (2012. J. Cell Biol. http://dx.doi.org/jcb.201201091) use these approaches to validate some aspects of the classical integrin regulation model; however, their data suggest that much of the regulation occurs after ligand binding rather than in preparation for ligand binding to occur.

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