Affordable Access

Publisher Website

A Dynamical Model of Oocyte Maturation Unveils Precisely Orchestrated Meiotic Decisions

Authors
Journal
PLoS Computational Biology
1553-734X
Publisher
Public Library of Science
Publication Date
Volume
8
Issue
1
Identifiers
DOI: 10.1371/journal.pcbi.1002329
Keywords
  • Research Article
  • Biology

Abstract

Author Summary In the life cycle of sexual organisms, a specialized cell division -meiosis- reduces the number of chromosomes in gametes or spores while fertilization or mating restores the original number. The essential feature that distinguishes meiosis from mitosis (the usual division) is the succession of two rounds of division following a single DNA replication, as well as the arrest at the second division in the case of oocyte maturation. The fact that meiosis and mitosis are similar but different raises several interesting questions: What is the meiosis-specific dynamics of cell-cycle regulators? Are there mechanisms which guarantee the occurence of two and only two rounds of division despite the presence of intrinsic and extrinsic noises ? The study of a model of the molecular network that underlies the meiotic maturation process in Xenopus oocytes provides unexpected answers to these questions. On the one hand, the modular organization of this network ensures separate controls of the first and second divisions. On the other hand, regulatory synergies ensure that these two stages are precisely and reliably sequenced during meiosis. We conclude that cells have evolved a sophisticated regulatory network to achieve a robust, albeit flexible, meiotic dynamics.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Mouse Oocyte Maturation: Meiotic Checkpoints

on Experimental Cell Research Jan 01, 1995

Nitric oxide inhibits oocyte meiotic maturation.

on Biology of reproduction November 2002

Mouse oocyte maturation: meiotic checkpoints.

on Experimental Cell Research August 1995

The control of meiotic maturation in mammalian ooc...

on Current topics in developmenta... 2013
More articles like this..