Affordable Access

Publisher Website

Practical heavy fluorous tag for carbohydrate synthesis with minimal chromatographic purification

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
51
Issue
50
Identifiers
DOI: 10.1016/j.tetlet.2010.10.016

Abstract

Abstract A practical heavy fluorous tag 5 bound to a benzylic linker was prepared and applied to carbohydrate synthesis. The fluorous tag 5 was readily introduced to the desired hydroxyl group and carboxyl group by using various methods. Synthesis of the oligosaccharide, which included the terminal structure of class III mucin, was achieved with single-column chromatographic purification. In addition, because of the symmetrical structure of 5, each fluorous synthetic intermediate could be analyzed much easier by NMR spectroscopy than in the case of the fluorous compounds connecting our previous fluorous tags.

There are no comments yet on this publication. Be the first to share your thoughts.