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Precise Determination ofT1Relaxation Values by a Method in Which Pairs of Nonequilibrium Magnetizations Are Measured across a Constant Relaxation Period

Journal of Magnetic Resonance Series A
Elsevier - Academic Press
Publication Date
DOI: 10.1006/jmra.1995.1024


Abstract The constant- relaxation- period (CREPE) method for spin-lattice ( T 1) relaxation measurement presented here offers a significant improvement over other methods currently in use. The CREPE approach involves the measurement of both the initial and the final magnetizations flanking a constant relaxation period; the relaxation rates can be extracted from the data by linear regression without the necessity of additional parameters to correct for off-resonance effects or errors in pulse-width settings. Computer simulations used to compare the accuracy of T 1 measurements made by the new method with those by the fast inversion-recovery (FIR) approach (generally considered to be the best general method for T 1 measurements) showed that the CREPE method provides about a twofold reduction in errors over a wide range of signal-to-noise in the input data. Experimental data collected by the two approaches showed that the CREPE method provides the same precision in T 1 values as the FIR method with one-fourth the data-collection time.

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