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The Optimization of Breast Conservation

International Journal of Breast Cancer
Hindawi Publishing Corporation
Publication Date
DOI: 10.4061/2011/456378
  • Editorial
  • Biology
  • Ecology
  • Geography
  • Medicine


SAGE-Hindawi Access to Research International Journal of Breast Cancer Volume 2011, Article ID 456378, 1 page doi:10.4061/2011/456378 Editorial The Optimization of Breast Conservation William C. Dooley,1 Mo Keshtgar,2 Tibor Tot,3 Daigo Yamamoto,4 and Mahmoud B. El-Tamer5 1 The University of Oklahoma, Oklahoma City, OK 73104, USA 2 Royal Free and University College Medical School, University College London, London wc1 6BT, UK 3 Uppsala University, Osaka 570-8506, Sweden 4 Department of Surgery, Kansai Medical University, Japan 5 Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA Correspondence should be addressed to William C. Dooley, [email protected] Received 2 November 2011; Accepted 2 November 2011 Copyright © 2011 William C. Dooley et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This issue includes information from the innovative research ongoing in breast cancer to increase our efficacy and thera- peutic choices to adequately treat breast cancers with breast conservation. First a couple of articles address the biologic issues that form the basis of current therapies and how these may be improved with new biologic understandings. We are beginning to recognize that the breast is not one paired organ but two collections of intertwined ductal lobular trees. Most if not all breast cancers only involve a single ductal tree at the time of clinical detection. All the other ductal trees are at risk and may have both synchronous and metachronous lesions that can progress or regress based on biologic and environmental pressures. As we understand breast cancer biology better we may have opportunities to detect cancers earlier, prevent cancers, and optimize conservation with more accurate and precise treatment. Oncoplastic surgery has given the prospect of breast conservation with r

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