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Effect of L-carnitine supplementation on the sGC/cGMP pathway in vascular relaxing responses from exercised rats

BMC Pharmacology
Springer (Biomed Central Ltd.)
Publication Date
DOI: 10.1186/1471-2210-9-s1-p54
  • Poster Presentation

Abstract ral ss BioMed CentBMC Pharmacology Open AccePoster presentation Effect of L-carnitine supplementation on the sGC/cGMP pathway in vascular relaxing responses from exercised rats Fernanda BM Priviero*1, Julio A Rojas-Moscoso2, Alexandre S Silva1, Edson Antunes2 and Angelina Zanesco1 Address: 1Department of Physical Education, São Paulo State University, UNESP, Rio Claro 13906-900, SP, Brazil and 2Department of Pharmacology, State University of Campinas, UNICAMP, Campinas 13084-970, SP, Brazil Email: Fernanda BM Priviero* - [email protected] * Corresponding author Background It has been largely documented the beneficial effects of physical training on the endothelium-derived relaxing response by increasing nitric oxide production and/or its bioavailability to the smooth muscle [1]. L-carnitine (L- Car) has been used as important supplement to regulate body composition associated with lipid metabolism. However, no studies exist investigating the effect of L-Car intake associated with dynamic exercise on the NO-inde- pendent sGC/cGMP pathway in the vascular responsive- ness in rats. Thus, the aim of this work was to investigate the effect of L-Car supplementation on the NO-independ- ent sGC/cGMP pathway in aortic and mesenteric rings in trained rats. Methods Male Wistar rats (344 ± 6 g) were divided into three groups: sedentary (SD), sedentary supplemented (SDS) and trained supplemented (TRS). Animals were trained in a treadmill with an intensity of 70–80% of maximal oxy- gen consumption, in sessions of 60 minutes, 5 days a week. Run training (RT) was performed simultaneously to L-Car intake (0.2 g/kg daily, given in the drinking water) for 4 weeks. Concentration-response curves were obtained for sodium nitroprusside (SNP) in isolated aortic and mesenteric rings. Plasma SOD activity and catalase levels Results Oral supplementation with L-Car associated with run training provoked a significant reduction in body weight gain (368 ± 13 g) as compare

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