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The cell biology of bone

Authors
Journal
Baillière s Clinical Rheumatology
0950-3579
Publisher
Elsevier
Publication Date
Volume
7
Issue
3
Identifiers
DOI: 10.1016/s0950-3579(05)80071-8

Abstract

Summary Bone remodelling and repair are accomplished by the co-ordinated activity of cells of the osteoclast and osteoblast lineages. Small changes in the balance between formation and resorption will, when magnified by repeated cycles, lead to significant reduction in bone mass and strength, ultimately resulting in fracture. This review focuses on the cellular features of bone remodelling and the known regulators of bone cell function. These include systemic and local factors, both soluble and contained within the complex extracellular matrix of bone.

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