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Electrolytic99mTcO4−reduction: A different pathway to obtain99mTc-labelled compounds

Authors
Journal
International Journal of Radiation Applications and Instrumentation Part A Applied Radiation and Isotopes
0883-2889
Publisher
Elsevier
Publication Date
Volume
42
Issue
7
Identifiers
DOI: 10.1016/0883-2889(91)90038-3
Disciplines
  • Chemistry

Abstract

Abstract Electrolytic reduction of 99mTcO 4 − at inert electrodes to obtain 99mTc cationic complexes and in vitro stability of labelled compounds were studied. Amines were used as neutral N-donor ligands and a systematic analysis of various parameters involved in the reduction process was performed. Usefulness of electrolytic reduction was proved as an alternative 99mTc-labelling method. Its most important advantages are: production of complexes with a high radiochemical purity, negligible presence of red-hyd- 99mTc, lack of foreign materials, simplicity of development and possibility of further applications.

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