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Stereochemical studies on the polyene macrolide nystatin A1: the hydroxyl groups in the C-1—C-10 fragment are all-syn

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
29
Issue
23
Identifiers
DOI: 10.1016/0040-4039(88)85222-5

Abstract

Abstract Two monoacetylated fragments 1 and 2 corresponding to the C-1—C-10 portion of nystatin A 1 have been prepared by controlled degradation. The 3R, 5R and 7R relative configurations at the asymmetric centers of these fragments were determined by 2D-proton phase-sensitive DQF-COSY nmr and nOe difference spectroscopy.

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