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A decrease in maternal plasma concentrations of sVEGFR-2 precedes the clinical diagnosis of preeclampsia

Authors
Journal
American Journal of Obstetrics and Gynecology
0002-9378
Publisher
Elsevier
Publication Date
Volume
202
Issue
6
Identifiers
DOI: 10.1016/j.ajog.2010.04.002
Keywords
  • Angiogenesis
  • Biomarker
  • Longitudinal Study
  • Mechanisms Of Disease
  • Pregnancy-Induced Hypertension
Disciplines
  • Biology
  • Medicine

Abstract

Objective The aim of this study was to examine if maternal plasma concentrations of soluble vascular endothelial growth factor receptor (sVEGFR)-2 change prior to the diagnosis of preeclampsia. Study Design A longitudinal study was conducted in normal pregnant women (n = 160) and patients with preeclampsia (n = 40). Blood samples were collected at 7 gestational age intervals from 6 weeks to term. Plasma concentrations of sVEGFR-2 were determined by enzyme-linked immunosorbent assay. Analysis was performed with cross-sectional and longitudinal (mixed effects model) approaches. Results Mothers destined to develop preeclampsia have lower plasma sVEGFR-2 concentrations than those who will have a normal pregnancy (longitudinal approach; P < .05). Cross-sectional analysis suggested that the median plasma sVEGFR-2 concentration in women destined to develop preeclampsia was significantly lower than that in normal pregnant women from 28-31 weeks of gestation ( P = .001) or 6-10 weeks prior to the diagnosis ( P < .001). Conclusion A lower maternal plasma sVEGFR-2 concentration precedes the development of preeclampsia, both term and preterm.

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