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Biliary metabolites of14C-estrone and14C-estradiol from the rat

Authors
Journal
Steroids
0039-128X
Publisher
Elsevier
Publication Date
Volume
18
Issue
3
Identifiers
DOI: 10.1016/0039-128x(71)90045-6
Keywords
  • 2-Hydroxyestrone = 2
  • 3-Dihydroxy-1
  • 5(10)-Estratrien-17-One 2-Methoxyestrone = 3-Hydroxy-2-Methoxy-1
  • 5(10)-Estratrien-17-One 2-Hydroxyestrone 3-Methyl Ether = 2-Hydroxy-3-Methoxy-1
  • 5(10)-Estratrien-17-One 2-Hydroxyestradiol = 1
  • 5(10)-Estratrien-2
  • 17β-Triol

Abstract

Abstract Estrone, 2-hydroxyestrone, 2-methoxyestrone, 2-hydroxyestrone 3-methyl ether, estradiol-17β and 2-hydroxyestradiol-17β have been identified as biliary “glucuronide” metabolites of radioactive estrone and estradiol from the rat. 2-Hydroxyestrone vas conjugated at the 2 position. This is the first report of an in vivo conversion of estrone and estradiol to 2-hydroxyestrone 3-methyl ether.

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