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Structural studies of an immunoenhancing glucan of an ectomycorrhizal fungusRamaria botrytis

Authors
Journal
Carbohydrate Research
0008-6215
Publisher
Elsevier
Publication Date
Volume
374
Identifiers
DOI: 10.1016/j.carres.2013.03.023
Keywords
  • Ectomycorrhizal Fungus
  • Ramaria Botrytis
  • Glucan
  • Nmr Studies
  • Immunostimulating Activity

Abstract

Abstract A water-soluble glucan was isolated from the alkaline extract of an ectomycorrhizal fungus, Ramaria botrytis. On the basis of sugar analysis, methylation analysis, Smith degradation, partial hydrolysis, and 1D/2D NMR studies, the structure of the repeating unit of the glucan was established as: This glucan showed immunostimulating activity by NO production on RAW 264.7, a murine macrophage cell line. Splenocyte and thymocyte proliferation were measured using, respectively, single cell suspensions of spleen and thymus obtained from normal mice.

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