Purpose Evaluate the usefulness of toric intraocular lens (IOL) implantation during cataract surgery in patients after penetrating keratoplasty (PKP). Design Retrospective case review. Participants A total of 21 eyes of 16 patients with prior PKP and moderate to high regular astigmatism after full suture removal underwent phacoemulsification and implantation of a single-piece acrylic toric IOL (SN6AT series; Alcon, Fort Worth, TX). Methods Patients underwent comprehensive examinations at standard intervals, including visual acuity, manifest refraction, and corneal topography. Main Outcome Measures Uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (CDVA) expressed as the logarithm of the minimum angle of resolution (logMAR) and manifest refraction astigmatism. Results From preoperatively to the last visit (mean, 14.7 ± standard deviation 12.8 months), the 21 eyes had significant improvement in UDVA (logMAR, 0.90±0.48 to 0.23±0.25; P = 0.0001) and CDVA (logMAR, 0.31±0.14 to 0.08±0.13; P = 0.0001). A total of 14 of 21 eyes (67%) and 17 of 21 eyes (81%) had UDVA and CDVA of ≥20/30, respectively. Preoperative topographic astigmatism was 4.57±2.05 diopters (D). Postoperative manifest refraction astigmatism was 1.58±1.25 D overall, but lower (0.75±0.54 D) in the T7–T9 subgroup (excluding 1 outlier whose corneal astigmatism doubled after surgery) than in the T4–T6 subgroup (1.88±1.28 D; P = 0.013). A total of 16 of all 21 eyes (76.2%) and 8 of 9 eyes (89%) in the T7–T9 subgroup were within 1 D of postoperative manifest astigmatism as predicted or better. Conclusions Toric IOLs placed during cataract surgery after PKP and full suture removal can reduce manifest refraction cylinder to predictably low levels with corresponding improvement in UDVA and CDVA in patients with moderate to high regular preoperative topographic astigmatism. Financial Disclosure(s) The author(s) have no proprietary or commercial interest in any materials discussed in this article.