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Synthesis of 9-[11C]methylamino-1,2,3,4-tetrahydroacridine, a potent acetylcholine esterase inhibitor

Authors
Journal
International Journal of Radiation Applications and Instrumentation Part A Applied Radiation and Isotopes
0883-2889
Publisher
Elsevier
Publication Date
Volume
42
Issue
7
Identifiers
DOI: 10.1016/0883-2889(91)90042-y

Abstract

Abstract A method is described by which 3.7 GBq (100 mCi) of a derivative of tetrahydroaminoacridine (THA): N-[ 11C]methyl THA may be obtained from about 55.5 GBq (1.5 Ci) of [ 11C]CO 2. THA is methylated with [ 11C]methyl iodide after deprotonation by sodium hydride in dimethyl sulphoxide at 100°C. The specific activity averages 35 GBq/μmol (950 mCi/μmol) at the end of synthesis (total time of synthesis: 45 min from EOB).

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