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Glucocorticoids potentiate kainic acid-induced seizures and wet dog shakes

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
480
Identifiers
DOI: 10.1016/0006-8993(89)90200-x
Keywords
  • Kainic Acid
  • Adrenalectomy
  • Dexamethasone
  • Wet Dog Shake
  • Seizure

Abstract

Abstract Glucocorticoid effects on kainic acid-induced motor seizures and wet dog shakes in rats were investigated by adrenalectomy and dexamethasone treatment. One-day adrenalectomy attenuated kainic acid-induced wet dog shakes and seizure activity. These effects were restored by dexamethasone. Administration of dexamethasone to non-adrenalectomized rats potentiated kainic acid-induced wet dog shakes and severity of seizure activity. These results suggest that glucocorticoids may play an important role in modulating the severity of kainic acid-induced seizures and wet dog shakes.

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