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Estimation of apparent tumor vascular permeability from multiphoton fluorescence microscopic images of P22 rat sarcomas in vivo.

Authors
Journal
Microcirculation
1073-9688
Publisher
Wiley Blackwell (Blackwell Publishing)
Publication Date
Volume
15
Issue
1
Identifiers
DOI: 10.1080/10739680701436350
Keywords
  • Algorithms
  • Animals
  • Capillary Permeability
  • Dextrans
  • Fluorescein-5-Isothiocyanate
  • Image Processing
  • Computer-Assisted
  • Microcirculation
  • Microscopy
  • Fluorescence
  • Neoplasm Transplantation
  • Neoplasms
  • Connective Tissue
  • Neovascularization
  • Pathologic
  • Rats
  • Rats
  • Inbred Strains
  • Sarcoma

Abstract

To develop an image processing-based method to quantify the rate of extravasation of fluorescent contrast agents from tumor microvessels, and to investigate the effect of the tumor vascular disrupting agent combretastatin A-4-P (CA-4-P) on apparent tumor vascular permeability to 40 kDa fluorescein isothiocyanate (FITC) labeled dextran.

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