Affordable Access

Publisher Website

Understanding the importance of selenium and selenoproteins in muscle function

Authors
Journal
Cellular and Molecular Life Sciences
1420-682X
Publisher
Springer-Verlag
Publication Date
Volume
63
Issue
1
Identifiers
DOI: 10.1007/s00018-005-5313-y
Keywords
  • Review
Disciplines
  • Biology
  • Medicine

Abstract

Abstract. Selenium is an essential trace element. In cattle, selenium deficiency causes dysfunction of various organs, including skeletal and cardiac muscles. In humans as well, lack of selenium is associated with many disorders, but despite accumulation of clinical reports, muscle diseases are not generally considered on the list. The goal of this review is to establish the connection between clinical observations and the most recent advances obtained in selenium biology. Recent results about a possible role of selenium-containing proteins in muscle formation and repair have been collected. Selenoprotein N is the first selenoprotein linked to genetic disorders consisting of different forms of congenital muscular dystrophies. Understanding the muscle disorders associated with selenium deficiency or selenoprotein N dysfunction is an essential step in defining the causes of the disease and obtaining a better comprehension of the mechanisms involved in muscle formation and maintenance.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Understanding the importance of selenium and selen...

on Cellular and Molecular Life Sc... January 2006

Selenium, selenoproteins and vision.

on Developments in ophthalmology 2005

Specificity of selenium uptake by selenoproteins.

on Nutrition reviews February 1991

Selenium and selenoproteins in the rat kidney

on Biochimica et Biophysica Acta... Jan 01, 1982
More articles like this..