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Clinical use of piracetam in epileptic patients

Authors
Journal
Current Therapeutic Research
0011-393X
Publisher
Elsevier
Publication Date
Volume
52
Issue
3
Identifiers
DOI: 10.1016/s0011-393x(05)80407-2
Disciplines
  • Design
  • Medicine

Abstract

Abstract In a double-blind, randomized, controlled study, we investigated the effects of piracetam, a nootropic compound, on cognitive disturbances and the potency of antiepileptic drugs in 60 epileptic patients and 15 age-matched control subjects. Each subject was given the following tests at the time of entry and 3 and 5 weeks after the start of treatment: memory for design test, Wechsler Intelligence Scale for Children/Wechsler Adult Intelligence Scale subtests, electroencephalography, and a neurologic examination. Our findings suggest that piracetam has a positive influence on cognitive measures in epileptic patients. In addition, piracetam does not diminish the antiepileptic effects of anticonvulsant drugs. Instead, it improved seizure protection in patients receiving carbamazepine.

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