Affordable Access

Publisher Website

XDR Tuberculosis: A Looming Threat

Authors
Journal
Indian Journal of Community Medicine
0970-0218
Publisher
Medknow Publications
Publication Date
Volume
34
Issue
2
Identifiers
DOI: 10.4103/0970-0218.51215
Keywords
  • Letters To Editor
Disciplines
  • Medicine

Abstract

Sir, Grover, et al. have reviewed the recent advances in drug resistant tuberculosis.(1) In this regard, it is important not to forget the recent threat of extensively drug resistant (XDR) tuberculosis that is resistant to isoniazid, rifampin, a fluoroquinolone, and any injectable drug (aminoglycosides or polypetides).(2) The cases of XDR have been reported from across the globe. It is also a cause of major concern in India.(3) This strain requires multiple second-line drugs for treatment and early reports indicated very high case fatality rates. This was probably due to concurrent HIV infection.(2) In this entire gloomy scenario, there is at least one silver lining from the recent report from Peru. In that report, individualized treatment of HIV-negative XDR cases yielded results comparable to MDR tuberculosis.(4) The importance for India lies in the fact that Peru, much like us, is a developing country. The objective for us, however, is to prevent the emergence and transmission of such a strain. The most important risk factor implicated in the occurrence of XDR cases is inadequate or inappropriate management of tuberculosis. Hence, there is an urgent need to strengthen services of DOTS and DOTS-Plus under RNTCP. Only an efficient first-line therapy in the form of DOTS can stop XDR tuberculosis from being a major public health concern in the days to come.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Extensively drug-resistant (XDR) tuberculosis: an...

on Annali dell'Istituto superiore... 2007

XDR-TB--a global threat.

on The Lancet Sep 16, 2006

Extensively Drug-Resistant Tuberculosis (XDR-TB) -...

on The Open Respiratory Medicine... Jan 01, 2007

Extensively drug resistant tuberculosis (XDR-TB):...

on Journal of basic and clinical... December 2010
More articles like this..