Affordable Access

Publisher Website

Placental transfer of stobadine in rabbits

Authors
Journal
Life Sciences
0024-3205
Publisher
Elsevier
Publication Date
Volume
65
Identifiers
DOI: 10.1016/s0024-3205(99)00467-1
Keywords
  • Antioxidant
  • Stobadine
  • Placental Transfer
  • Rabbit

Abstract

Abstract Stobadine, a pyridoindole antioxidant, was investigated for its placental transfer and distribution in New Zealand white rabbits on the 27th day of gestation. The concentrations of stobadine were determined in maternal and foetal organs (plasma, brain, heart) at 30, 60, 120, and 360 minutes after oral administration of the drug in a dose of 5 mg/kg. The results obtained proved that after oral stobadine intake by rabbits at the stage of advanced pregnancy both maternal and foetal organs were under a certain drug level which could act protectively against oxidative stress — frequently occurring during late organogenesis, foetal stages and delivery, as well as during early postnatal development.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Placental transfer of the antioxidant stobadine at...

on Methods and findings in experi... November 2000

Placental transfer of palmitic acid-1-C14 in rabbi...

on American Journal of Obstetrics... Oct 15, 1962

Placental transfer of L-tyrosine in rabbits.

on Biochimica et Biophysica Acta Apr 25, 1966
More articles like this..