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Calmodulin activity in yeast and mycelial phases ofCeratocystis ulmi

FEMS Microbiology Letters
Oxford University Press
Publication Date
  • Ceratocystis Ulmi
  • Calmodulin
  • Dimorphism
  • Calcium
  • Trifluoperazine
  • Cyclic Nucleotide Phosphodiesterase


Abstract The yeast and mycelial phases of Ceratocystis ulmi contained roughly equivalent levels of calmodulin activity as determined by their ability to stimulate calmodulin-deficient bovine brain cAMP phosphodiesterase. This stimulation was calcium-dependent and could be inhibited by either dibucaine or trifluoperazine. Also, the concentration of dibucaine necessary to achieve the mycelium-to-yeast morphological conversion was found to be 3-fold greater in the presence of exogenous calcium. A model is presented in which only 30% of the cellular calmodulin need be complexed with calcium ions for mycelial development.

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