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The identification of flunitrazepam and its metabolites in urines samples

Authors
Journal
Analytica Chimica Acta
0003-2670
Publisher
Elsevier
Publication Date
Volume
170
Identifiers
DOI: 10.1016/s0003-2670(00)81739-0

Abstract

Abstract A thin-layer chromatographic method with fluorescence detection is described for the identification of flunitrazepam and its metabolites in urine. The method is based on the hydrolysis and subsequent formation of acridine derivatives by cyclization in dimethylformamide and is selective for benzodiazepines with a 2-fluorophenyl group. The method is applicable to urine samples even after an oral dose of only 2 mg of flunitrazepam. Flunitrazepam and flurazepam consumption can be distinguished.

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