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T-wave alternans negative coronary patients with low ejection and benefit from defibrillator implantation

Authors
Journal
The Lancet
0140-6736
Publisher
Elsevier
Publication Date
Volume
362
Issue
9378
Identifiers
DOI: 10.1016/s0140-6736(03)13865-2
Keywords
  • Primary Research
  • Research Letters
Disciplines
  • Medicine

Abstract

Summary In a trial of prophylactic implantation of a defibrillator, a mortality benefit was seen among patients with previous myocardial infarction and a left-ventricular ejection fraction of 0·30 or less. We identified 129 similar patients from two previously published clinical trials in which microvolt T-wave alternans testing was prospectively assessed. At 24 months of follow-up, no sudden cardiac death or cardiac arrest was seen among patients who tested T-wave alternans negative, compared with an event rate of 15·6% among the remaining patients. Testing of T-wave alternans seems to identify patients who are at low risk of ventricular tachyarrhythmic event and who may not benefit from defibrillator therapy.

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