Abstract Fatigue crack growth behaviour of A533B steel was investigated in pressurized water at 288 °C using specimens machined from four different orientations. When inclusions were oriented along the direction of crack propagation, fatigue crack growth rate (FCGR) was enhanced compared to when they were perpendicular to the direction of crack propagation. At low Δ K levels FCGR in ambient water was slightly higher than that in 288 °C water. This may be attributed to the occurrence of intergranular cracking in ambient water tested specimen. Though mainly ductile striations were observed on the fracture surfaces, isolated intergranular facets (in a specimen tested in ambient water) and fan shaped features were also present. Hydrogen induced damage was clearly evident in the ambient water tested specimen in the form of isolated intergranular facets.