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Glucagonlike peptide-1 (7–36)amide suppresses glucagon secretion and decreases cyclic AMP concentration in cultured in-R1-G9 cells

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
186
Issue
1
Identifiers
DOI: 10.1016/s0006-291x(05)80836-8

Abstract

Summary We previously reported that GLP-1(7–36)amide had glucagonostatic action as well as insulinotropic action in the perfused rat pancreas. In this study, we examined the effect of GLP-1(7–36)amide on glucagon secretion and cAMP concentration in glucagon-secreting cell line, In-Rl-G9. GLP-1(7–36)amide (1nM) significantly suppressed glucagon secretion and decreased cAMP concentration in the cells. GLP-1(1–37) did not affect glucagon secretion. It is suggested that inhibitory effect of GLP-1(7–36)amide on glucagon secretion is at least partly mediated by adenylate cyclase system.

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