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Capture and Release of Alkyne-Derivatized Glycerophospholipids Using Cobalt Chemistry

Authors
Journal
Nature Chemical Biology
1552-4450
Publisher
Nature Publishing Group
Publication Date
Volume
6
Issue
3
Identifiers
DOI: 10.1038/nchembio.311
Source
Legacy
Keywords
  • Article

Abstract

Alkyne modified phospholipids can be unambiguously identified and differentiated from native species in complex mixtures by formation of dicobalthexacarbonyl complexes. This reaction is specific for alkynes and is unaffected by other glycerophospholipid related moieties. Enrichment of cells with alkyne-derivatized fatty acids or glycerophospholipids followed by solid phase sequestration and release is a promising new method for unequivocally monitoring individual glycerophospholipids following incorporation and facilitates lipidomic analysis of substrates and products.

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