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Cerebrospinal fluid and neuropathological study in Devic's syndrome:Evidence of intrathecal immune activation

Authors
Journal
Journal of the Neurological Sciences
0022-510X
Publisher
Elsevier
Publication Date
Volume
82
Identifiers
DOI: 10.1016/0022-510x(87)90024-4
Keywords
  • Devic'S Syndrome
  • Neuromyelitis Optica
  • Igg
  • Cerebrospinal Fluid
  • Neuropathology
  • Isoelectric Focusing
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Cerebrospinal fluid (CSF) was studied in 2 cases of Devic's syndrome (DS). In one of these cases autopsy was carried out. The main CSF feature in DS is the association of blood-brain barrier damage and intrathecal IgG synthesis. These findings are in keeping with our neuropathological observation of diffuse central nervous system vasculitis and leptominingitis. As a whole, our CSF and neuropathological findings in DS are consistently different from those in multiple sclerosis.

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