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Narrowband ultraviolet B phototherapy is a suitable treatment option for solar urticaria

Authors
Journal
Journal of the American Academy of Dermatology
0190-9622
Publisher
Elsevier
Volume
67
Issue
1
Identifiers
DOI: 10.1016/j.jaad.2011.01.030
Keywords
  • Clinical Trial
  • Minimal Erythemal Dose
  • Minimal Urticarial Dose
  • Narrowband Ultraviolet B Phototherapy
  • Phototest
  • Solar Urticaria
Disciplines
  • Medicine
  • Physics

Abstract

Background Narrowband (NB) ultraviolet (UV) B lamps are widely used for treatment and prophylaxis of several skin diseases. Objective We sought to assess the efficacy of two protocols of NB-UVB therapy for the prophylaxis of UVB-sensitive and UVB-insensitive solar urticaria (SU). Methods Subjects affected by SU underwent phototesting for assessment of the minimal erythemal dose and minimal urticarial dose. Patients without urticarial response to UVB underwent a single daily exposure every other day for 4 weeks (group A). Patients with a urticarial test response to broadband UVB or NB-UVB (group B) received 3 daily exposures (on working days) for the first week. Afterward, they were treated as the patients of group A for 3 weeks. Follow-up visits took place after 1 and 3 months. Results A total of 39 patients completed the study. In groups A (29 patients) and B (10 patients), the median total number of exposures was 12 (interquartile range [IQR]: 12; 15) and 25.5 (IQR 24; 27), respectively. The median total NB-UVB dose was 10.3 J/cm2 (IQR 9.9; 11) for group A and 9.1 J/cm2 (IQR 8.5; 10.6) for group B. At follow-up visits, patients reported good tolerance to the sun. Limitations A direct comparison of NB-UVB with UVA or psoralen plus UVA for the photoprophylaxis of SU is still lacking. Conclusion NB-UVB phototherapy was well-tolerated and effectively prevented SU relapses.

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