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The Structure of an Endosomal Protein Sorter

Authors
Journal
Developmental Cell
1534-5807
Publisher
Elsevier
Publication Date
Volume
7
Issue
4
Identifiers
DOI: 10.1016/j.devcel.2004.09.007
Disciplines
  • Biology

Abstract

Abstract Three “endosomal sorting complexes required for transport,” ESCRT-I, -II, and -III, mediate sorting of ubiquitinated membrane proteins into intraluminal endosomal vesicles that are destined for degradation in lysosomes. Two recent reports, one in Nature and one in this issue of Developmental Cell, reveal the crystal structure of the yeast form of ESCRT-II.

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