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EVALUASI IMUNOSEROLOGI PADA BAYI PASCA IMUNISASI HEPATITIS B LENGKAP

Authors
Publisher
Buletin Penelitian Kesehatan
Publication Date
Keywords
  • Health
  • Kesehatan
  • Hepatitis B
  • Immunization
  • Immunoserology
Disciplines
  • Mathematics
  • Medicine

Abstract

EVALUASI IMUNOSEROLOGI PADA BAY1 PASCA IMUNISASI HEPATITIS B LENGKAP Muljati ~rijanto' , Sarwo ~andayani ' , Bambang ~erijanto' , Farida S' , ~umarno' IMMUNO-SEROLOGICAL EVALUATION OF INFANTS IMMUNIZED WITH HEPA TITIS B VACCINE Abstract. A serological evaluation was conducted to assess the hepatitis B (HB) vaccination ejfectiveness among children with age 1-2 years of age in Sumedang regency. Blood samples for antibody determination were obtained from 239 infants from Situ, Cimalaka and South Sumedang districts. The results showed that the HbsAg prevalence among infants in the study areus was 1.7% and the proportion of infants with negative titer was 5.5%. Most (55%) infants were immunized at age 1 month and 29% of the infants received the immunization between ages 0-7 cluys. The percentage of infants who developed protective HB antibody from the three ciistricts was 91.58% with mean geometric titer of 68,1653 mlU/ml. The highest percentage of infants with protective antibody level was in Cimalaka district, i.e. 96,25%. The results of immunization coverage of three HB doses in Sumedang district in 1999 and 2000 were 91.75% und 91.29% respectively. This study concluded that the percentage of protected ififants post immunization with three doses of HB in Sumedang regency has not changed significantly in comparison with immunization coverage that was reported in 1999 and 2000. 2 Keyword: Hepatitis B, immunization, immunoserology PENDAHULUAN Hepatitis B adalah penyakit infeksi yang merupakan masalah kesehatan utama di negara berkembang dan padat pendu- duknya. Indonesia terrnasuk negara dengan endemisitas sedang sampai tinggi dengan prevalensi berkisar antara 5-20%. Angka prevalensi hepatitis B pada ibu hamil rata- antara anak umur 4 Bhun dari 6.25% men- jadi 2% ('). Imunisasi hepatitis B mulai diinte- grasikan ke dalam Program Imunisasi secara bertahap di empat provinsi mulai tahun 1991, kemudian di 10 provinsi pada tahun 1992 dan akhirnya men

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