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γ-aminobutyric acid levels in the intercellular space in the nucleus accumbens of the rat brain during a nociceptive conditioned response

Authors
  • Saul'skaya, N. B.
  • Marsden, Ch. A.
Type
Published Article
Journal
Neuroscience and Behavioral Physiology
Publisher
Kluwer Academic Publishers-Plenum Publishers
Publication Date
Jan 01, 1998
Volume
28
Issue
1
Pages
60–64
Identifiers
DOI: 10.1007/BF02461913
Source
Springer Nature
Keywords
License
Yellow

Abstract

Studies on Lister rats, using intracerebral dialysis in behaving animals combined with high-performance liquid chromatography with electrochemical detection, showed that the development and realization of an emotional conditioned response were accompanied by increases in the γ-aminobutyric acid (GABA) levels in the extracellular space of the medial part of the nucleus accumbens. Regression analysis demonstrated that measures of investigative behavior (horizontal movements, rearings, and sniffing and grooming times) during quenching of the emotional conditioned response (but not on presentation of the experimental chamber to control rats) correlated with individual changes in the extracellular GABA levels in the nucleus accumbens. Thus, this is the first report ofin vivo recording of changes in GABA levels in the extracellular space of the brain during realization of normal behavior.

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