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β-Glucan exacerbates allergic asthma independent of fungal sensitization and promotes steroid-resistant TH2/TH17 responses.

Authors
  • Zhang, Zhonghua1
  • Biagini Myers, Jocelyn M1
  • Brandt, Eric B1
  • Ryan, Patrick H2
  • Lindsey, Mark1
  • Mintz-Cole, Rachael A1
  • Reponen, Tiina3
  • Vesper, Stephen J4
  • Forde, Frank1
  • Ruff, Brandy1
  • Bass, Stacey A1
  • LeMasters, Grace K5
  • Bernstein, David I6
  • Lockey, James3
  • Budelsky, Alison L7
  • Khurana Hershey, Gurjit K8
  • 1 Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
  • 2 Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
  • 3 Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio.
  • 4 Environmental Protection Agency, Cincinnati, Ohio.
  • 5 Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio.
  • 6 Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
  • 7 Department of Inflammation Research, Amgen, Seattle, Wash.
  • 8 Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address: [email protected]
Type
Published Article
Journal
The Journal of allergy and clinical immunology
Publication Date
Jan 01, 2017
Volume
139
Issue
1
Identifiers
DOI: 10.1016/j.jaci.2016.02.031
PMID: 27221135
Source
Medline
Keywords
License
Unknown

Abstract

Our data demonstrate that fungi are potent immunomodulators and have powerful effects on asthma independent of their potential to act as antigens. Furthermore, our results provide a strong rationale for combination treatment strategies targeting IL-17A for this subgroup of fungus-exposed patients with difficult-to-treat asthma.

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