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Β-defensins - Underestimated peptides in influenza combat.

Authors
  • Kalenik, Barbara Małgorzata1
  • Góra-Sochacka, Anna1
  • Sirko, Agnieszka2
  • 1 Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A, 02-106 Warsaw, Poland. , (Poland)
  • 2 Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A, 02-106 Warsaw, Poland. Electronic address: [email protected] , (Poland)
Type
Published Article
Journal
Virus research
Publication Date
Mar 02, 2018
Volume
247
Pages
10–14
Identifiers
DOI: 10.1016/j.virusres.2018.01.008
PMID: 29421304
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Defensins are a family of host defense peptides present in vertebrates, invertebrates and plants. They display broad antimicrobial activity and immunomodulatory functions. Herein, the natural anti-influenzal role of β-defensins, as well as their potential usage as anti-influenza vaccine adjuvants and therapeutic agents, is reviewed. This article summarizes previously published information on β-defensin modes of action, expression changes after influenza infection and vaccination, biotechnological usage and possible boosting of their production by dietary supplementation. Copyright © 2018 Elsevier B.V. All rights reserved.

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