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β-Catenin-Dependent Wnt Signaling: A Pathway in Acute Cutaneous Wounding.

Authors
  • Carre, Antoine L1
  • Hu, Michael S
  • James, Aaron W
  • Kawai, Kenichiro
  • Galvez, Michael G
  • Longaker, Michael T
  • Lorenz, H Peter
  • 1 Stanford, Calif. From the Hagey Laboratory for Pediatric Regenerative Medicine, Stanford University School of Medicine.
Type
Published Article
Journal
Plastic and reconstructive surgery
Publication Date
Mar 01, 2018
Volume
141
Issue
3
Pages
669–678
Identifiers
DOI: 10.1097/PRS.0000000000004170
PMID: 29481398
Source
Medline
License
Unknown

Abstract

The authors' data suggest that β-catenin-dependent Wnt signaling expression increases shortly after cutaneous wounding, and exogenous rmWnt3a accelerates reepithelialization, wound matrix maturation, and scar formation. Future experiments will focus on the intersection of Wnt signaling and other known profibrotic cytokines.

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