Published in Human Heredity
Objectives: Identifying drivers of complex traits from the noisy signals of genetic variation obtained from high-throughput genome sequencing technologies is a central challenge faced by human geneticists today. We hypothesize that the variants involved in complex diseases are likely to exhibit non-neutral evolutionary signatures. Uncovering the ev...
Published in Linguistic Typology
The Database of Cross-Linguistic Colexifications (CLICS), has established a computer-assisted framework for the interactive representation of cross-linguistic colexification patterns. In its current form, it has proven to be a useful tool for various kinds of investigation into cross-linguistic semantic associations, ranging from studies on semanti...
Published in Genome Biology
We have designed a zebrafish genomic microarray to identify DNA-protein interactions in the proximal promoter regions of over 11,000 zebrafish genes. Using these microarrays, together with chromatin immunoprecipitation with an antibody directed against tri-methylated lysine 4 of Histone H3, we demonstrate the feasibility of this method in zebrafish...
Published in Open Physics
A lattice model with a spatial dispersion corresponding to a power-law type is suggested. This model serves as a microscopic model for elastic continuum with power-law non-locality. We prove that the continuous limit maps of the equations for the lattice with the power-law spatial dispersion into the continuum equations with fractional generalizati...
Published in Boundary-Layer Meteorology
Meteorological modelling in the planetary boundary layer (PBL) over Greater Paris is performed using the Weather Research and Forecast (WRF) numerical model. The simulated meteorological fields are evaluated by comparison with mean diurnal observational data or mean vertical profiles of temperature, wind speed, humidity and boundary-layer height fr...
Published in Genome Biology
BackgroundHuman immunity relies on the coordinated responses of many cellular subsets and functional states. Inter-individual variations in cellular composition and communication could thus potentially alter host protection. Here, we explore this hypothesis by applying single-cell RNA-sequencing to examine viral responses among the dendritic cells ...
Published in PloS one
Current efforts to understand antibiotic resistance on the whole genome scale tend to focus on known genes even as high throughput sequencing strategies uncover novel mechanisms. To identify genomic variations associated with antibiotic resistance, we employed a modified genome-wide association study; we sequenced genomic DNA from pools of E. coli ...
Published in Neurodegenerative Diseases
Functional and structural plasticity is a fundamental property of the brain involving chemical, electrical, molecular and cellular responses and leading to reorganization of connections within a brain region and/or between brain regions. The Notch pathway has been recognized as one of the main contributors in regulating neural development and has b...
Published in Neuropsychobiology
Background: The results of studies examining the response to experimental pain during the menstrual cycle are conflicting because of differences in the definitions of the menstrual period, outcome measures and types of experimental pain stimulation. So far, there have been only a few studies correlating experimental pain with the levels of gonadal ...
Published in Nature Ecology & Evolution
Microbial communities may often be composed of a wide diversity of taxa that perform similar functions. Here, the authors discuss the roles of function, functional redundancy and taxonomy in microbial community assembly and coexistence.
