Rhabdomyosarcoma (RMS) represents more than 50% of paediatric soft tissue tumours. Conversely, it is extremely rare among adults, where it shows peculiar biological and clinical features that are still poorly investigated. RMS patients should be referred to a Sarcoma Centre, where the contribution of experienced radiologists plays a relevant role i...
Endotoxemia induced by lipopolysaccharide (LPS) is an extremely severe syndrome identified by global activation of inflammatory responses. Neutrophil extracellular traps (NETs) play an important role in the development of endotoxemia. Histone hypercitrullination catalyzed by peptidylarginine deiminases (PADs) is a key step of NET formation. We have...
PURPOSE: To examine physical activity (PA) patterns from pre- to post-diagnosis, and compare these changes to women without breast cancer. To determine pre-diagnosis predictors of PA change, post-diagnosis, in breast cancer survivors (BCS). METHODS: Data were from 2314 Study of Women's Health Across the Nation (SWAN) participants, average age of 46...
Published in Neuropsychobiology
Background: The results of studies examining the response to experimental pain during the menstrual cycle are conflicting because of differences in the definitions of the menstrual period, outcome measures and types of experimental pain stimulation. So far, there have been only a few studies correlating experimental pain with the levels of gonadal ...
The COVID-19 pandemic has caused many people to lose income because of pay cuts, lay-offs, or furloughs. This loss of income can be very scary and may be the first time you’ve been on your own and out of work. It can be overwhelming to figure out how to pay your different bills (e.g., school loans, credit cards, rent, food, etc.). In order to make ...
The goals of this presentation are to: define the molecular structure of Gram-negative organisms; highlight differences between Gram-negatives and Gram-positives; discuss the most important clinically-relevant Gram-negative bacteria; review treatments for Gram-negatives; and illustrate clinical scenarios involving Gram-negative infection.
The abundant cellular protein Cyclophilin A (CypA) was found to bind to HIV-1 capsid (CA) in 1993. Since that time, several complementary methods, including disruption of the binding interface by cyclosporine A, CA mutants, and CypA mutants, have been used to demonstrate that CypA acts within human target cells to promote HIV-1 infection. In contra...
The design, synthesis, and X-ray structural analysis of hybrid HIV-1 protease inhibitors (PIs) containing bis-tetrahydrofuran (bis-THF) in a pseudo-C2-symmetric dipeptide isostere are described. A series of PIs were synthesized by incorporating bis-THF of darunavir on either side of the Phe-Phe isostere of lopinavir in combination with hydrophobic ...
INTRODUCTION: During the COVID-19 pandemic, central venous access line teams were implemented at many hospitals throughout the world to provide access for critically ill patients. The objective of this study was to describe the structure, practice patterns and outcomes of these vascular access teams during the COVID-19 pandemic. METHODS: We conduct...
The 2019 novel coronavirus' (COVID-19) pandemic became apparent in China during the International Congress on Epidermolysis Bullosa, (EB) in London, in January 2020. Many EB patients have medical problems that make them a vulnerable population of patients. Herein, we developed an international consensus to suggest best management of EB patients dur...
