Advanced Computational Methods for Knowledge Engineering
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Cryo-EM study of an archaeal 30S initiation complex gives insights into evolution of translation initiation
Published in Communications Biology
Coureux et al. describe a cryo-EM structure of a 30S initiation complex of Pyrococcus abyssi at 3.2Å resolution. The structure uncovers a novel archaeal ribosomal protein aS21, N-terminal extension of eL41 and brings insights into base modifications of the rRNA.
Porcine sialoadhesin suppresses type I interferon production to support porcine reproductive and respiratory syndrome vi...
Published in Veterinary Research
Porcine reproductive and respiratory syndrome virus (PRRSV) is a significant threat to the global swine industry. Porcine sialoadhesin (poSn) has been previously shown to mediate PRRSV attachment and internalization. In the current study, we report its unidentified role in antagonism of type I interferon (IFN) production during PRRSV infection. We ...
Deep learning versus parametric and ensemble methods for genomic prediction of complex phenotypes
Published in Genetics Selection Evolution
BackgroundTransforming large amounts of genomic data into valuable knowledge for predicting complex traits has been an important challenge for animal and plant breeders. Prediction of complex traits has not escaped the current excitement on machine-learning, including interest in deep learning algorithms such as multilayer perceptrons (MLP) and con...
Identification of the ABCC4, IER3, and CBFA2T2 candidate genes for resistance to paratuberculosis from sequence-based GW...
...Published in Genetics Selection Evolution
BackgroundBovine paratuberculosis is a contagious disease, caused by Mycobacterium avium subsp. paratuberculosis (MAP), with adverse effects on animal welfare and serious economic consequences. Published results on host genetic resistance to MAP are inconsistent, mainly because of difficulties in characterizing the infection status of cows. The obj...
Malaria epidemiology in Kobeni department, southeastern Mauritania from 2015 to 2017
Published in Infectious Diseases of Poverty
BackgroundPlasmodium falciparum malaria is endemic in the southern sahelian zone of Mauritania where intense internal and trans-border human and livestock movement occurs. The risk of importation and spread of drug-resistant parasites need to be regularly assessed in this region. The objective of the study was to assess the recent malaria situation...
Parkinson’s disease with early motor complications: predicting EQ-5D- 3L utilities from PDQ-39 data in the EARLYSTIM tri...
Published in Health and Quality of Life Outcomes
BackgroundA utility value is a health-related quality of life metric (HRQoL) metric used in a cost-effectiveness analysis. While utilities as outcomes in the treatment of advanced Parkinson’s disease (PD) with deep brain stimulation (DBS) are available, they do not currently exist for PD with early motor complications. The objectives of this study ...
A deterministic equation to predict the accuracy of multi-population genomic prediction with multiple genomic relationsh...
Published in Genetics Selection Evolution
BackgroundA multi-population genomic prediction (GP) model in which important pre-selected single nucleotide polymorphisms (SNPs) are differentially weighted (MPMG) has been shown to result in better prediction accuracy than a multi-population, single genomic relationship matrix (GRM\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{was...
Probabilistic modeling to estimate jellyfish ecophysiological properties and size distributions
Published in Scientific Reports
While Ocean modeling has made significant advances over the last decade, its complex biological component is still oversimplified. In particular, modeling organisms in the ocean system must integrate parameters to fit both physiological and ecological behaviors that are together very difficult to determine. Such difficulty occurs for modeling Pelag...
Aging-simulation experience: impact on health professionals’ social representations
Published in BMC Geriatrics
BackgroundHealth professionals working with older persons are not sufficiently aware of the sensory and functional difficulties experienced by older patients. Innovative educational activities, such as the aging-simulation experience, can facilitate this awareness. This study describes the effects of an aging-simulation experience on health profess...
