Published in Kompass Neumología
Background: Occupational exposures have been regarded as a risk factor for the development of chronic obstructive pulmonary disease (COPD). However, there is little knowledge regarding the effect of occupational exposure on the treatment outcomes of COPD. Therefore, the aim of this study was to evaluate the question of whether occupational exposure...
Published in Kompass Onkologie
Host immunity plays a central role in the regulation of anti-tumour responses during checkpoint inhibitor therapy (CIT). The mechanisms involved in long lasting remission remain unclear. Animal studies have revealed that the microbiome influences the host immune response. This is supported by human studies linking a higher microbial richness and di...
Published in Skin Appendage Disorders
Introduction: Alopecia areata (AA) is a common autoimmune disease characterized by non-scarring hair loss. New onsets of AA have been associated with coronavirus disease 2019 (COVID-19). Various skin diseases have already been reported because of the vaccines (the Pfizer-BioNTech COVID-19 vaccine, the Moderna COVID-19 vaccine, the AstraZeneca vacci...
Published in Kompass Neumología
Background: Hospital work environment contains various biological and chemical exposures that can affect indoor air quality and have impact on respiratory health of the staff. The objective of this study was to investigate potential effects of occupational exposures on the risk of respiratory symptoms and lung function in hospital work, and to eval...
Published in Kompass Onkologie
Published in Kompass Onkologie
Hintergrund: Die chronische myeloische Leukämie ist eine hämatologische Malignität, die mit der Fusion von zwei Genen einhergeht: BCR und ABL1. Diese Fusion resultiert aus einer Translokation zwischen den Chromosomen 9 und 22, auch als Philadelphia Chromosom bekannt. Obwohl das Philadelphia-Chromosom bei mehr als 90% der Patienten mit chronischer m...
Published in Kompass Onkologie
Background: Older patients with metastatic pancreatic cancer may suffer increased toxicity from intensive chemotherapy. Treatment individualization by geriatric assessment (GA) might improve functional outcome. Methods: We performed a multicenter, phase IV, open label trial in patients ≥70 years with metastatic pancreatic adenocarcinoma. Patients u...
Published in Kompass Onkologie
Patients with chronic myeloid leukemia in chronic phase (CML-CP) resistant/intolerant to ≥2 tyrosine kinase inhibitors (TKIs) are at high risk of experiencing poor outcomes because of disease biology and inadequate efficacy and/or safety of current therapies. Asciminib, a first-in-class BCR-ABL1 inhibitor Specifically Targeting the ABL Myristoyl Po...
Published in Kompass Onkologie
In der IMCgp100-202 Studie wurden zuvor unbehandelte HLA-A*02:01-positive Patienten mit metastasiertem Aderhautmelanom im Verhältnis 2:1 nach dem Zufallsprinzip entweder mit Tebentafusp (Tebentafusp-Gruppe) oder einer Therapie nach Wahl des Prüfarztes mit Pembrolizumab, Ipilimumab oder Dacarbazin (Kontrollgruppe) behandelt, stratifiziert nach dem L...
Published in Kompass Onkologie
In patients with transplant-ineligible newly diagnosed multiple myeloma (NDMM), daratumumab reduced the risk of disease progression or death by 44% in MAIA (daratumumab/lenalidomide/dexamethasone [D-Rd]) and 58% in ALCYONE (daratumumab/bortezomib/melphalan/prednisone [D-VMP]). Minimal residual disease (MRD) is a sensitive measure of disease and res...
