Pathogenic variants in BRCA1 and BRCA2 only explain the underlying genetic cause of about 10% of hereditary breast and ovarian cancer families. Because of cost-effectiveness, multigene panel testing is often performed even if the clinical utility of testing most of the genes remains questionable. The purpose of our study was to assess the contribut...
Low-complexity non-smooth convex regular-izers are routinely used to impose some structure (such as sparsity or low-rank) on the coefficients for linear predictors in supervised learning. Model consistency consists then in selecting the correct structure (for instance support or rank) by regularized empirical risk minimization. It is known that mod...
International audience
OBJECTIVE:To determine whether changing antiretroviral therapy (ART) during pregnancy because of concern about fetal risks led to poorer virological outcomes.METHODS:All pregnancies in women with HIV-1 infection enrolled in the national multicenter prospective French Perinatal cohort at 14 week gestation or more were included between January 2005 a...
Osteoarthritis is the most common degenerative joint disease. Spectral computed tomography generates energy-resolved data which enable identification of materials within the sample and offer improved soft tissue contrast compared to conventional X-ray CT. In this work, we propose a realistic numerical phantom of a knee to assess the feasibility of ...
Predicting the evolution of nitrate pollution at the catchment scale implies a global evaluation of residence timesand denitrification rates in the aquifer. Data acquired in wells only result from processes occurring in their capturezone and are rarely representative of the whole aquifer [1]. Stream data, on the opposite, integrate the processesocc...
Understanding how and why global climate tipped from greenhouse to icehouse conditions remains a major challenge.This critical shift is well documented in the marine realm characterized by a steady decline in global temperatureuntil a large and rapid cooling step at the Eocene-Oligocene Transition (EOT). However, the chronology andmechanisms of coo...
This paper introduces an augmented model for first-order opinion dynamics, in which a weight of influence is attributed to each agent. Each agent's influence on another agent's opinion is then proportional not only to the classical interaction function, but also to its weight. The weights evolve in time and their equations are coupled with the opin...
The large dark cores of common dwarf galaxies are unexplained by the standard heavy particle interpretation of dark matter because gravity is scale free (1-3), so the particle density should continuously rise towards the center of galaxies. This puzzle is exacerbated by the discovery of a very large but barely visible, dark matter dominated galaxy ...
The ability to predict the progression of biomarkers, notably in NDD, is limited by the size of the longitudinal data sets, in terms of number of patients, number of visits per patients and total follow-up time. To this end, we introduce a data augmentation technique that is able to reproduce the variability seen in a longitudinal training data set...
