Kubitschke, Martin Masseck, Olivia A.
Published in
Biological Chemistry
Understanding how neuronal networks generate complex behavior is one of the major goals of Neuroscience. Neurotransmitter and Neuromodulators are crucial for information flow between neurons and understanding their dynamics is the key to unravel their role in behavior. To understand how the brain transmits information and how brain states arise, it...
Falconieri, Alessandro Coppini, Allegra Raffa, Vittoria
Published in
Biological Chemistry
Microtubules are highly polar structures and are characterized by high anisotropy and stiffness. In neurons, they play a key role in the directional transport of vesicles and organelles. In the neuronal projections called axons, they form parallel bundles, mostly oriented with the plus-end towards the axonal termination. Their physico-chemical prop...
Hörner, Sarah Janice Couturier, Nathalie Hafner, Mathias Rudolf, Rüdiger
Published in
Biological Chemistry
Neuromuscular cell culture models are used to investigate synapse formation and function, as well as mechanisms of de-and regeneration in neuromuscular diseases. Recent developments including 3D culture technique and hiPSC technology have propelled their ability to complement insights from in vivo models. However, most cultures have not considered ...
Altahini, Saleh Arnoux, Isabelle Stroh, Albrecht
Published in
Biological Chemistry
To exploit the full potential of optogenetics, we need to titrate and tailor optogenetic methods to emulate naturalistic circuit function. For that, the following prerequisites need to be met: first, we need to target opsin expression not only to genetically defined neurons per se, but to specifically target a functional node. Second, we need to as...
Wu, Zhi-Cong Lin, Ke-Na Li, Xue-Qi Ye, Xin Chen, Hua Tao, Jun Zhou, Hang-Ning Chen, Wen-Jie Lin, Dong-Feng Xie, Shang-Hang
...
Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives Epstein-Barr virus (EBV) C promoter (Cp) hypermethylation, a crucial factor for EBV latent infection of nasopharyngeal epithelial cells, has been recognized as a promising biomarker for nasopharyngeal carcinoma (NPC) detection. In this study, we develop a novel EBV Cp methylation quantification (E-CpMQ) assay and evaluate its diagnostic ...
Greytak, Sarah R. Engel, Kelly B. Hoon, Dave S.B. Elias, Kevin M. Lockwood, Christina M. Guan, Ping Moore, Helen M.
Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Circulating cell-free microRNAs (cfmiRNA) are an emerging class of biomarkers that have shown great promise in the clinical diagnosis, treatment, and monitoring of several pathological conditions, including cancer. However, validation and clinical implementation of cfmiRNA biomarkers has been hindered by the variability introduced during different ...
Laryea, Erving T. Mitchell, Kelsey Hernández, Julia Stanford, Eric Twum, Kwaku Wiencek, Joesph R.
Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Lee, Kwang Seob Lee, Choong-Kun Kwon, Soon Sung Kwon, Woo Sun Park, Sejung Lee, Seung-Tae Choi, Jong Rak Rha, Sun Young Shin, Saeam
Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives Clonal hematopoiesis (CH) is a condition in which healthy individuals have somatic mutations in hematopoietic stem cells. It has been reported with increased risk of hematologic malignancy and cardiovascular disease in the general population, but studies of Korean populations with comorbid disease entities are scarce. Methods White blood...
Joshi, Kriti Harris, Mark Cotterill, Andrew Wentworth, John M. Couper, Jennifer J. Haynes, Aveni Davis, Elizabeth A. Lomax, Kate E. Huynh, Tony
Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Type 1 diabetes (T1D) is well-recognised as a continuum heralded by the development of islet autoantibodies, progression to islet autoimmunity causing beta cell destruction, culminating in insulin deficiency and clinical disease. Abnormalities of glucose homeostasis are known to exist well before the onset of typical symptoms. Laboratory-based test...
González-Cejudo, Trinidad Villa-Suárez, Juan Miguel Ferrer-Millán, María Andújar-Vera, Francisco Contreras-Bolívar, Victoria Andreo-López, María Carmen Gómez-Vida, José María Martínez-Heredia, Luis González-Salvatierra, Sheila de Haro Muñoz, Tomás
...
Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives Since the prevalence of hypophosphatasia (HPP), a rare genetic disease, seems to be underestimated in clinical practice, in this study, a new diagnostic algorithm to identify missed cases of HPP was developed and implemented. Methods Analytical determinations recorded in the Clinical Analysis Unit of the Hospital Universitario Clínico Sa...
