Is telomere length a biomarker of sperm quality? A systematic review and meta‐analysis of observational studies
Published in Andrology
Is telomere length a biomarker of sperm quality? A systematic review and meta‐analysis of observational studies
Forty-two normomenstruating adolescents with Müllerian obstructive anomalies: Presentation, pitfalls in the dagnosis and...
Published in Acta Obstetricia Et Gynecologica Scandinavica
We analyzed the frequency, presentation and pitfalls in the diagnosis and surgical management of a large group of normomenstruating adolescents with obstructive reproductive tract anomalies. Retrospective analysis of prospectively collected data. Of the 143 outpatients referred for severe dysmenorrhea and persistent pelvic pain, 42 (29.3%) young wo...
Novel engineered nanobodies specific for N-terminal region of alpha-synuclein recognize Lewy-body pathology and inhibit ...
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Published in FEBS Journal
Nanobodies (Nbs), the single-domain antigen-binding fragments of dromedary heavy-chain antibodies (HCAb), are excellent candidates as therapeutic and diagnostic tools in synucleinopathies because of their small size, solubility and stability. Here, we constructed an immune nanobody library specific to the monomeric form of alpha-synuclein (α-syn). ...
Immune priming depends on age, sex and Wolbachia in the interaction between Armadillidium vulgare and Salmonella.
Published in Journal of Evolutionary Biology
The protection conferred by a first infection upon a second pathogenic exposure (i.e. immune priming) is an emergent research topic in the field of invertebrate immunity. Immune priming has been demonstrated in various species, but little is known about the intrinsic factors that may influence this immune process. In this study, we tested whether a...
Identification of compounds that inhibit the binding of Keap1a/Keap1b Kelch DGR domain with Nrf2 ETGE/DLG motifs in zebr...
Published in Basic & Clinical Pharmacology & Toxicology
The Keap1-Nrf2-ARE system serves as a premier defence mechanism to curb oxidative stress, which remains as one of the major causes of ageing and pathogenesis in various diseases. Nrf2 is the principal master regulator of the cellular defence system, and its activation remains the prospective therapeutic approach against chronic diseases. One of the...
Autoantibodies to full body vascular cell junctions colocalize with MYZAP, ARVCF, desmoplakins I and II and p0071 in end...
Published in International Journal of Dermatology
Background We previously described a new variant of endemic pemphigus foliaceus in El Bagre, Colombia (El Bagre-EPF).
Patients with a new variant of endemic pemphigus foliaceus have autoantibodies against arrector pili muscle, colocalizin...
Published in Clinical and Experimental Dermatology
BACKGROUND: We identified a new variant of endemic pemphigus foliaceus in El Bagre, Colombia, South America, which we term El Bagre-EPF, and observed reactivity to arrector pili muscle (APM), thus we tested for autoimmunity to APM. METHODS: We took skin biopsies from 30 patients with El Bagre-EPF and 30 healthy controls (HCs) matched by age,...
Effects of seasonality, transport pathway, and spatial structure on greenhouse gas fluxes in a restored wetland.
Published in Global Change Biology
Wetlands can influence global climate via greenhouse gas (GHG) exchange of carbon dioxide (CO2 ), methane (CH4 ), and nitrous oxide (N2 O). Few studies have quantified the full GHG budget of wetlands due to the high spatial and temporal variability of fluxes. We report annual open-water diffusion and ebullition fluxes of CO2 , CH4 , and N2 O from a...
Agroecological management of a soil-dwelling orthopteran pest in vineyards
Published in Insect Science
The efficacy of different combinations of undervine and inter‐row treatments for managing a soil‐dwelling orthopteran pest, weta (Hemiandrus sp.), in vineyards was investigated over 2 seasons. This insect damages vine buds, thus reducing subsequent grape yield. The undervine treatments comprised pea straw mulch, mussel shells, tick beans [Vicia fab...
Netrin G1: its downregulation in the nucleus accumbens of cocaine-conditioned mice and genetic association in human coca...
...Published in Addiction Biology
Netrin G1 is a presynaptic ligand involved in axonal projection. Although molecular mechanisms underlying cocaine addiction are still poorly understood, Netrin G1 might have a role as a regulator of anxiety, fear and spatial memory, behavioural traits impaired in the context of cocaine exposure. In this study, the Netrin G1 (Ntng1) expression was i...
